The top spot goes to ti-ligers/ti-tigon/li-tigons/li-ligers because it is a hybrid among the hybrids. It is a cross breed between a male tiger and a female liger/tigon or a male lion with a female tigon/liger. Do note that female ligers or tigons are fertile. They are extremely rare and are in mostly private ownership within a behavioural studies programme. In the case of ti-ligers, they have unusual striping where it breaks up and display a blotchy appearance. Since they are 3/4 tiger, their characteristics inhibit more of those of a tiger than a lion.
A zorse is the result of crossbreeding a horse and a zebra. A zonkey is the result of crossbreeding a donkey with a zebra. The Zony is the result of crossbreeding a pony to a zebra. All these three are called zebroids - defined as a cross between a zebra and any other equid. Zebroids are preferred over zebra for practical uses such as riding because of its body shape. However it is more inclined to be temperamental and can prove to be difficult to handle.
Though they are fascinating animals, they get the last of the list because they are the most popular known among the hybrids. Ligers are crossbreeds between a male lion while Tigons are crossbreds between a male tiger and a female lion. Ligers are the world's largest cats. Tigons on the other hand, are prone towards dwarfism and are usually smaller than either of their parents. Male Ligers/Tigons are sterile while the females are often fertile. Below shows a liger and its trainer Dr. Bhagavan Antle at a Renaissance Festival in Massachusetts, USA, October 2005.
A wolphin is a rare hybrid formed from a cross between a bottlenose dolphin and a false killer whale. There are currently only two in captivity at the Sea Life Park in Hawaii. A wolphin's size, colour and shape are intermediate between the parent species. The first captive wolphin was Kekaimalu, which shows mixed heritage even in its teeth: bottlenose dolphins have 88, false killer whales have 44 and Kekaimalu has 66!
Dogs and wolves tend to crossbreed rather freely. The wolf is a shy animal depending on nuances in body language, facial expression and on hunting skills to survive. Their jaws are much stronger than those of a dog and are often used to exert dominance. For a dog wolf hybrid, it is not known when it will display a wolf behaviour or dog behaviour or something in between. Obedience training is a must in order to tame the animal.